Michael Basler Selected Research

PR-957

1/2022	Immunoproteasome Inhibition Reduces the T Helper 2 Response in Mouse Models of Allergic Airway Inflammation.
1/2022	Effective therapy of polymyositis in mice via selective inhibition of the immunoproteasome.
12/2018	Co-inhibition of immunoproteasome subunits LMP2 and LMP7 is required to block autoimmunity.
1/2018	Immunoproteasome Inhibition Impairs T and B Cell Activation by Restraining ERK Signaling and Proteostasis.
1/2016	Inhibiting the immunoproteasome exacerbates the pathogenesis of systemic Candida albicans infection in mice.
1/2014	Inhibition of the immunoproteasome ameliorates experimental autoimmune encephalomyelitis.
10/2012	Immunoproteasome subunit LMP7 deficiency and inhibition suppresses Th1 and Th17 but enhances regulatory T cell differentiation.
7/2009	A selective inhibitor of the immunoproteasome subunit LMP7 blocks cytokine production and attenuates progression of experimental arthritis.

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Michael Basler Research Topics

Disease

9	Infections 01/2021 - 11/2003
6	Autoimmune Diseases (Autoimmune Disease) 11/2021 - 10/2012
4	Inflammation (Inflammations) 01/2022 - 07/2010
4	Neoplasms (Cancer) 11/2021 - 02/2012
4	Disease Progression 11/2020 - 01/2007
4	Colitis 12/2018 - 07/2010
3	Virus Diseases (Viral Diseases) 01/2021 - 11/2009
3	Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) 12/2018 - 02/2013
2	Multiple Myeloma 11/2020 - 11/2009
2	Weight Loss (Weight Reduction) 01/2018 - 07/2010
1	Myositis (Idiopathic Inflammatory Myopathies) 01/2022
1	Polymyositis 01/2022
1	Muscle Weakness 01/2022
1	Breast Neoplasms (Breast Cancer) 02/2020
1	Colitis-Associated Neoplasms 01/2019
1	ZAP70 deficiency 01/2018
1	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 01/2018
1	Colonic Neoplasms (Colon Cancer) 01/2018
1	Severe Combined Immunodeficiency (Bare Lymphocyte Syndrome) 01/2018
1	Systemic candidiasis 01/2016
1	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 11/2015
1	Meningitis 01/2015
1	Pain (Aches) 01/2015
1	Arthritis (Polyarthritis) 10/2012
1	Human Influenza (Influenza) 08/2012
1	Rheumatoid Arthritis 07/2009
1	Experimental Arthritis 07/2009
1	Prostatic Neoplasms (Prostate Cancer) 01/2007

Drug/Important Bio-Agent (IBA)

8	PR-957IBA 01/2022 - 07/2009
7	EpitopesIBA 11/2015 - 09/2004
6	Proteasome Endopeptidase Complex (Proteasome)IBA 01/2021 - 09/2004
6	CytokinesIBA 01/2019 - 07/2009
3	Proteasome InhibitorsIBA 11/2020 - 11/2009
2	Proteins (Proteins, Gene)FDA Link 01/2022 - 01/2007
2	InterferonsIBA 01/2019 - 02/2013
2	Dextran SulfateIBA 01/2018 - 07/2010
2	Histocompatibility Antigens Class IIBA 01/2016 - 11/2009
2	Pharmaceutical PreparationsIBA 07/2015 - 10/2012
2	Peptides (Polypeptides)IBA 10/2012 - 01/2007
1	KZR-616IBA 01/2022
1	OvalbuminIBA 01/2022
1	Therapeutic UsesIBA 01/2022
1	glidobactin CIBA 02/2020
1	Interleukin-23 (Interleukin 23)IBA 10/2019
1	Messenger RNA (mRNA)IBA 01/2019
1	Interleukin-6 (Interleukin 6)IBA 12/2018
1	Ethylnitrosourea (N-Ethyl-N-nitrosourea)IBA 01/2018
1	Buprenorphine (Subutex)FDA LinkGeneric 01/2015
1	PolyubiquitinIBA 02/2013
1	Ubiquitinated ProteinsIBA 02/2013
1	Dextrans (Dextran)FDA Link 10/2012
1	sodium sulfate (sodium bisulfate)FDA LinkGeneric 10/2012
1	EndopeptidasesIBA 07/2010
1	T-Lymphocyte Epitopes (Epitopes, T Lymphocyte)IBA 11/2009
1	Bortezomib (Velcade)FDA Link 11/2009
1	AutoantibodiesIBA 07/2009
1	VaccinesIBA 01/2007
1	Hormones (Hormone)IBA 01/2007
1	prostatic acid phosphataseIBA 01/2007
1	Recombinant Fusion ProteinsIBA 01/2007
1	Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)IBA 01/2007
1	sipuleucel-T (APC8015)FDA Link 01/2007
1	NucleoproteinsIBA 11/2003

Therapy/Procedure

2	Therapeutics 01/2022 - 11/2020
2	Transplantation 11/2021 - 01/2019
1	Analgesia 01/2015
1	Immunotherapy 01/2007
1	Radiotherapy 01/2007
1	Prostatectomy (Retropubic Prostatectomy) 01/2007